Breeding the clavulanic acid high-production strain of Streptomyces clavuligerus by using interspecific protoplast fusion technique was studied. 采用棒状链霉菌种内原生质体融合技术,选育克拉维酸高产菌株。
Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus. 目的提高棒状链霉菌的克拉维酸生产能力,去除副产物头霉素C。
Antibiotics with more than 40% sensitivity rates were carbenicillin, mezlocillin, trimethoprim, ticarcillin, ticarcillin/ clavulanic acid. 对抗生素敏感≥40%的抗生素为羧苄西林、美洛西林、甲氧苄啶、头孢他啶、替卡西林、替卡西林/克拉维酸。
Amoxicillin/ clavulanic acid in sequential treatment of acute bacterial infection in emergency department 阿莫西林-克拉维酸序贯治疗急性细菌性感染在急诊科的应用
Clavulanate potassium ( calculated on the basis of clavulanic acid) and amoxicillin ( calculated on the basis of anhydrous) were 90.0%~ 110.0% of the labelled amount. 克拉维酸钾(以克拉维酸计)和阿莫西林(以无水物计)分别为其标示量的90.0%~110.0%。
Advances in β-lactamase inhibitor clavulanic acid β-内酰胺酶抑制剂克拉维酸研究进展
RESULTS: The concentration-time curves of amoxicillin and clavulanic acid conformed one-compartment modol. 结果:阿莫西林和克拉维酸药-时曲线均呈一室模型。
Effect of lat disruption on clavulanic acid production 棒状链霉菌lat基因的中断对棒酸产量的影响
CONCLUSION: amoxicillin/ clavulanic acid ( 14:1) is an effective and safe antibiotic for the treatment of acute respiratory tract and middle ear bacterial infection. 结论:阿莫西林克拉维酸片(14∶1)对呼吸道和中耳常见感染临床疗效好,使用安全。
Treatment of moderate and severe infection with ticarcillin/ clavulanic acid versus ceftazidime in 41 patients 替卡西林/克拉维酸和头孢他啶治疗中重度感染41例
When low concentration ( 0. lmg/ 100ml) iodoacetic acid was added to fermentation media in the beginning of fermentation to alter the catabolism pathway of saccharide, the biosynthesis of clavulanic acid was promoted obviously. 糖的代谢途径对克拉维酸的生物合成也有显著的影响,当添加低浓度(0.1。g/100ml)的碘乙酸改变糖的代谢途径时,明显促进了克拉维酸的生物合成。
Effect of pH value on precipitate in compatibility of amoxicillin/ clavulanic acid with other drugs 药液酸碱度对阿莫西林-克拉维酸与其他药物配伍产生沉淀的影响
Relative bioavailability of clavulanic acid/ amoxicillin dispersive tablets in healthy volunteers 克拉维酸/阿莫西林分散片与普通片的人体相对生物利用度研究
Optimization of clavulanic acid fermentation 克拉维酸发酵工艺的优化研究
The resistance of S. aureus to ampicillin, oxacillin and amoxicillin/ clavulanic acid was 81%, 38% and 31%, respectively. 11% and 16% of Pseudomonas aeruginosa resistant to Imipenem and Ceftazidime, respectively. 对氨苄青霉素、苯唑青霉素钠、羟氨苄青霉素克拉维酸耐药的金黄色葡萄球菌耐药率分别为81%、38%和31%,对亚胺培南和头孢他啶耐药的铜绿假单胞菌分别占11%和16%;
Objectives: To evaluate the efficacy and safety of Amoxycillin sulbactam injection compared with Amoxycillin clavulanic acid injection in the treatment of acute bacterial infections. 目的:通过以阿莫西林钠克拉维酸钾(安灭菌)为对照药进行临床研究,评价阿莫西林钠舒巴坦钠治疗常见致病菌引起的细菌感染性疾病的临床疗效和安全性。
Amoxicillin/ clavulanic acid ( 14 ∶ 1) in treatment of respiratory tract and middle ear bacterial infection 阿莫西林-克拉维酸(14∶1)片随机对照治疗呼吸道和中耳细菌性感染
AIM To study the relative bioavailability of clavulanic acid/ amoxicillin dispersive tablets. 目的利用反相液相色谱法比较克拉维酸/阿莫西林分散片与克拉维酸/阿莫西林普通片安奇的人体生物利用度。
The plasma amoxicillin and clavulanic acid concentration of the volunteers were determined by column-switching HPLC. 用柱切换HPLC内标法测定阿莫西林和克拉维酸血药浓度,由3P97药动学程序计算有关药代动力学参数。
Determination of Glycerol Content in Clavulanic Acid Broth by Spectrophotometry 克拉维酸发酵液中碳源&甘油含量的比色法测定
Objective: To compare the clinical efficacy and safety profile of ticarcillin/ clavulanic acid and ceftazidime in treatment of moderate and severe infection. 目的:比较替卡西林克拉维酸和头孢他啶治疗中重度感染的疗效及安全性。
Domestic vs imported amoxicillin/ clavulanic acid in treating pneumonia of children 国产和进口阿莫西林-克拉维酸治疗小儿肺炎的疗效比较
Bioequivalence of amoxicillin and clavulanic acid tablets in healthy volunteers The plasma concentration of clavulanic acid and amoxicillin simultaneous were determined with HPLC. 用HPLC法同时测定血浆中克拉维酸和阿莫西林的浓度,计算克拉维酸和阿莫西林的药代动力学参数,计算分散片的相对生物利用度。
The Study of Degradation of Clavulanic Acid in Ferment 发酵中克拉维酸降解因素的探讨
Optimization of Fermentation Medium of Clavulanic Acid by Analyzing Relational Grades 关联度分析法优化克拉维酸发酵培养基
Amoxicillin and amoxicillin/ clavulanic acid are commonly-used antibiotics in the treatment of pneumococcal infections, especially paediatric respiratory tract infection. Therefore, amoxicillin was selected to evaluate antibiotic selective pressure. 阿莫西林或阿莫西林/克拉维酸是临床治疗肺炎链球菌感染常用药物,尤其是儿科在治疗呼吸道感染的常用口服药物,所以本部分研究选取阿莫西林作为评价药物选择压力用药。